Endocrine Abstracts

Bone densitometry (DEXA) is the best method available today for diagnosing low bone density. However, DEXA is not able to differentiate osteoporosis from osteomalacia. The definitive diagnosis of osteomalacia is made by bone biopsy – rarely used in medical practice – which shows excess unmineralized bone. Tests of blood and urine may also be helpful: concentration of serum and urinary calcium and phosphorus, 25-hydroxyvitamin D and parathyroid hormone b...

The oral dosing with cholecalciferol needed to achieve and maintain optimal serum concentration 25-hydroxyvitamin D (25OHD) is still controversial.This study reports on the efficacy of supplementation with oral vitamin D3 1000 U/day for 3–18 months on serum 25OHD levels in 87 ambulatory patients with postmenopausal osteoporosis (mean age 63.5 years). Serum 25OHD, parathyroid hormone (PTH), calcium (serum, urine), phosphate, alkaline phosphatase and ...

It is established that the delayed puberty is the lack of development of sexual maturation in boys and girls at a chronological age that is 2.5 standard deviation above the mean age. Some possible causes of delayed puberty are: hypothalamic defects, pituitary defects or the gonads.Objectives: Early diagnosis of the gonadal insufficiency; identification of the bone mass and the bone turnover at the pacients with delayed puberty; prophylaxis measures of th...

Background: The delayed puberty is defined by absence of secondary sexual characters until the age of 16 or lack of puberty development until the limit of +2DS in regard to the age when the puberty begin normal at considered population. After the major factor implied in delayed puberty ethiology, can be distinguished three mechanisms: hypothalamic, hypophyseal and gonadal. It is recognized the fact that the osteoporosis process is, in the first place, dependent and interdepend...